2020 NIR Brain Photobiomodulation Therapeutic Instrument For
Traumatic Events 810nm Helmet
Mechanisms of Brain Photobiomodulation
Brain photobiomodulation (PBM) utilizes red to near-infrared (NIR)
photons to stimulate the cytochrome c oxidase enzyme
(chromophore/complex IV) of the mitochondrial respiratory chain
because this enzyme is receptive to light energy. This outcomes are
an increase in ATP synthesis, leading to the generation of more
cellular energy. Additionally, photon absorption by ion channels
results in release of Ca2+ which leads to the activation of
transcription factors and gene expression.
There are several mechanisms associated with promoting
physiological change through photobiomodulation therapy (PBMT). The
wavelengths primarily used with PBM is within the near-infrared
range of the electromagnetic spectrum with a sufficient power
density. When hypoxic/impaired cells are irradiated with low level
NIR photons, there is increased mitochondrial adenosine
tri-phosphate (ATP) production within their mitochondria. Another
change is the release of nitric oxide from the hypoxic/impaired
cells. Neurons are cells that contain mitochondria and nitric
In hypoxic neuronal cells, cytochrome-C oxidase (CCO), a
membrane-bound protein that serves as the end-point electron
acceptor in the cell respiration electron transport chain, becomes
inhibited by non-covalent binding of nitric oxide. When exposed to
NIR photons, the CCO releases nitric oxide, which then diffuses
outs of the cell – increasing local blood flow and vasodilation.
Following initial exposure to the NIR photons, there is a brief
burst of reactive oxygen species (ROS) in the neuron cell, and this
activates a number of signaling pathways. The ROS leads to
activation of redox-sensitive genes, and related transcription
factors including NF-κβ. The PBMT stimulates gene expression for
cellular proliferation, migration, and the production of
anti-inflammatory cytokines and growth factors.
- NIR light can penetrate the head and reach the brain.
- NIR is absorbed by cytochrome c oxidase in mitochondria.
- Heat-gated ion channels also play a role.
- Increased blood flow, energy, neuroprotection, less inflammation,
- Can treat traumatic (stroke, TBI), neurodegenerative and
|Name||Brain Photobiomodulation Machine|
|LED Wavelength||810 nm|
|Power(total helmet)||15 W|
|Power(one LED)||60 mW|
Feedback from customers:
What is the Brain?
The brain is the controller of the body’s movements and essential
functions, such as breathing and blood pressure, and also our
feelings, thoughts, and beliefs.
The brain is made up of billions of nerve cells which transmit
information using a combination of electrical and chemical
Its soft, jelly-like mass is cushioned inside the skull by
cerebrospinal fluid. This fluid circulates around the brain and
through a series of cavities in the brain called ventricles.
The brain is divided into a number of parts, which work together.
The more these parts are coordinated and in tune with each other,
the better the overall functioning of the brain.
The cerebral cortex is the largest part of the brain, and is
divided into two hemispheres, the left and right.
The Brain’s Hemispheres
The left hemisphere mainly controls speech and language (talking,
comprehension, reading, and writing).
The right hemisphere mainly controls visual perception and the
interpretation of nonverbal information, such as understanding
facial expressions and behavior.
Neurons are cells that contain mitochondria.
By delivering photons to a light-sensitive enzyme(cytochrome c
oxidase) found within the mitochondria, this triggers a cascade of
beneficial and energizing cellular events.
Some potential effects are : enhanced cognition, neuroprotective
effects, self-repair mechanisms
What is Brain Injury?
Brain Injury is the “multiple disabilities arising from damage to
the brain acquired after birth. It results in deterioration in
cognitive, physical, emotional or independent functioning. It can
be as a result of accidents, stroke, brain tumours, infection,
poisoning, lack of oxygen, degenerative neurological disease etc.”
The National Community Services Data Dictionary (Australian
Institute of Health and Welfare, Canberra, 2012)
Common Causes of Brain Injury
Traumatic Brain Injury occurs as the result of some external force
being applied to the brain.
Stroke usually occurs as the result of a haemorrhage or blockage to
the blood vessels that supply blood to the various regions of the
Tumours cause damage to the surrounding brain tissue and structures
as they grow within the brain.
Bacterial or viral infections can lead to an inflammation of the
brain covering (meningitis) or the brain tissue itself
Alcohol acts as a toxin and the long term misuse of alcohol can
cause damage to brain tissue.
Hypoxia/anoxia refers to reduced or, complete, stopping of the flow
of oxygen to the brain leading to injury to brain tissue. Can be
caused by overdoses, failed hangings, or near drowning.
Degenerative Neurological Diseases
Conditions including Huntington’s Disease, Parkinson’s Disease, and
Alzheimer’s Disease are caused by abnormal changes to brain cells
in particular regions of the brain.
About Brain Injury
The disability called brain injury – sometimes called acquired
brain injury, or “ABI” – refers to any damage to the brain that
occurs after birth. That damage can be caused by an accident or
trauma, by a stroke, by a brain infection, by alcohol or other drug
abuse or by diseases of the brain like Parkinson’s disease.
Brain injury is common. According to the Australian Bureau of
Statistics, over 700,000 Australians have a brain injury, with
daily “activity limitations” and “participation restrictions”.
Three in every four of these people are aged 65 or under. As many
as two out of every three acquired their brain injury before the
age of 25. Three-quarters of people with a brain injury are men.
1. Traumatic events (stroke, traumatic brain injury, and global
2. Degenerative diseases (dementia, Alzheimer's and Parkinson's).
3. Psychiatric disorders (depression, anxiety, post traumatic
The Brain’s Lobes
The brain is divided into a number of parts, or “lobes”, which work
together. When the brain’s lobes are coordinated and “in tune” with
each other, the brain fucntions better.
The frontal lobe is involved in problem-solving, planning, making
judgments, abstract thinking and regulating how people act upon
their emotions and impulses.
The area towards the back of the frontal lobe, called the motor
strip, helps to control movement. In the left hemisphere, the motor
strip controls movement of the right side of the body; in the right
hemisphere, it controls movement of the left side of the body.
The temporal lobe is involved in receiving and processing auditory
information like music and speech. It also helps to control
language comprehension, visual perception, memory, and learning.
The temporal lobe contains areas which control personality,
emotions and sexual behaviour.
The parietal lobe controls sensation and body position, as well as
allowing us to understand time, recognise objects, and judge the
position of objects around us.
The occipital lobe receives and interprets visual information about
colour, size, shape, and distance.
1. Avoid direct exposure to the eyes, pregnant women's abdomen,
melanoma, brown spots.
2. Taboo patients with early and middle stage malignant tumors.
3. Contraindications to patients with acute bleeding disorders.
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