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MK-1775 adavosertib cas 955365-80-7

Categories Active Pharmaceutical Ingredient
Brand Name: Crene
Model Number: cas 955365-80-7
Place of Origin: China
MOQ: 1g
Packaging Details: Packaging according to customer requirements.
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    MK-1775 adavosertib cas 955365-80-7

    Chemical Information
    Product name:MK-1775 adavosertibPurity:98% min
    CAS NO:955365-80-7Solubility:DMSO: 18.75 mg/mL
    Molecular Formula:C27H32N8O2Package:Package according to customer requirements
    Molecular Weight:500.595Storage:Store at -20℃
    Remarks

    MK-1775, also known as adavosertib, AZD-1775, is a WEE1 inhibitor, is also a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.


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